Hodgkin's disease is a rare but possible underlying cause of pericarditis, especially in cases with severe symptoms or a prolonged course.
Consider Hodgkin's in refractory pericarditis with lymphadenopathy; Level 5 data leave open any change to evaluation protocols.
Two patients presented with initial symptoms of pericarditis. Palpable lymph nodes developed a few weeks later and a diagnosis of Hodgkin's disease was made. Although rare, this mode of presentation of Hodgkin's disease has been reported previously, and it should be considered in the differential diagnosis of any patient with pericarditis with severe general symptoms or a prolonged course.
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Larsson et al. (1976) studied this question.
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