Why the study?
Target tissue concentrations correlate with effect and may be influenced by the number of administrations, but the impact of repeated bolus versus continuous infusion remained unclear.
Does continuous infusion of doxorubicin alter plasma and tissue concentrations compared to bolus infusion in a tumour-free porcine model?
Comparison
Bolus infusion vs continuous infusion of doxorubicin
Design
Randomized study
Follow-up
Day 22
Authors
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Animal data leave open whether infusion method affects doxorubicin efficacy in patients; no practice change warranted.
Does continuous infusion of doxorubicin alter plasma and tissue concentrations compared to bolus infusion in a tumour-free porcine model?
Continuous and bolus infusions of doxorubicin result in similar, low tissue concentrations in a porcine model, suggesting similar expected anti-neoplastic efficacy at the tissue level.
Jørgensen et al. (2025) studied this question.