Why the study?
Does severe obesity alter glomerular hemodynamics and function compared to healthy controls?
Population
21 subjects total: 12 nondiabetic subjects with severe obesity and 9 healthy control subjects.
Comparison
Severe obesity (observational exposure) vs Healthy control subjects
Design
Case-control
Authors
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Severe obesity linked to hyperfiltration; leaves open whether insulin resistance drives progression to CKD.
Does severe obesity alter glomerular hemodynamics and function compared to healthy controls?
Severe obesity is associated with increased GFR and RPF, likely driven by afferent arteriole vasodilation and increased transcapillary hydraulic pressure, which correlates strongly with insulin resistance.
Chagnac et al. (2000) studied this question.
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