Why the study?
Does alpha-methyldopa acutely lower mean blood pressure and plasma renin activity in anesthetized dogs?
Population
Dogs anesthetized with sodium pentobarbital, including a model with unilateral ligation of the right renal…
Design
Preclinical
Follow-up
acute
Authors
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Indicates alpha-methyldopa lowers blood pressure independently of renin suppression; leaves open clinical translation from this animal model.
Does alpha-methyldopa acutely lower mean blood pressure and plasma renin activity in anesthetized dogs?
Alpha-methyldopa lowers blood pressure independently of its adrenergic-mediated reduction in plasma renin activity.
Halushka et al. (1974) studied this question.
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