Key result
Renin activity assayed directly in plasma or plasma extracts corresponded well, demonstrating the comparability of the two methods for radioimmunoassay of angiotensin I.
Design
Other
Authors
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Supports direct plasma renin assays without extraction; leaves open need for broader standardization and clinical validation.
The study demonstrates that radioimmunoassay of angiotensin I can be reliably performed directly in plasma or plasma extracts, provided standards are processed identically to unknowns.
Katz et al. (1972) studied this question. Radioimmunoassay of Angiotensin I vs. Plasma vs plasma extracts was evaluated on Comparability of renin activity methods. Renin activity assayed directly in plasma or plasma extracts corresponded well, demonstrating the comparability of the two methods for radioimmunoassay of angiotensin I.
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