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January 1, 1973Clinical Science

Determination of Plasma Renin Activity by Radioimmunoassay of Angiotensin I

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Key result

A simple radioimmunoassay of angiotensin I established normal plasma renin activity at 1.17±0.90 ng ml−1 h−1, with altered levels observed in various hypertensive and renal conditions.

Population

n=21 normal subjects, and patients with essential hypertension, chronic glomerulonephritis with oedema…

Design

Other

Authors

SFS FukuchiImperial Household AgencyTTT TakeuchiOsaka University of Pharmaceutical SciencesTTT TorikaiTohoku University

Discussion

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Implication

Reference values for plasma renin activity may aid hypertension subtyping; leaves open validation against modern assays and outcomes.

Study Design

Type

Observational (n=21)

Structured PICO

P
Population
21 normal subjects and an unspecified number of patients with essential hypertension, chronic glomerulonephritis, renovascular hypertension, and primary aldosteronism.
E
Exposure
Radioimmunoassay of angiotensin I to measure plasma renin activity
O
Outcome
Plasma renin activity (estimated as the rate of generation of angiotensin I)surrogate

The study describes a simple and rapid radioimmunoassay for measuring plasma renin activity, demonstrating its utility in distinguishing various hypertensive and renal conditions.

Cite This Study

Fukuchi et al. (1973) conducted an observational in Hypertension and renal diseases (n=21). Radioimmunoassay of angiotensin I was evaluated on Plasma renin activity (rate of generation of angiotensin I). A simple radioimmunoassay of angiotensin I established normal plasma renin activity at 1.17±0.90 ng ml−1 h−1, with altered levels observed in various hypertensive and renal conditions.

synapsesocial.com/papers/6a955851cd304312aafa7bb4https://doi.org/10.1042/cs0440043

Topics

Hypertension managementSermorelin
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Application of a Radioimmunoassay for Angiotensin I to the Physiologic Measurements of Plasma Renin Activity in Normal Human Subjects11969 · 2,239 citations
  2. 2Measurement of Renin Activity in Human Plasma1965 · 246 citations
  3. 3The Quantitative Determination of Renin in the Plasma of Patients with Arterial Hypertension1963 · 117 citations
  4. 4Improved Method for Measurement of Renin Activity in Human Plasma1969 · 12 citations
  5. 5Improved Assay Methods for Renin "Concentration" and "Activity" in Human Plasma1967 · 401 citations