Ureaplasmas were isolated from 141 (53.4%) of 264 men suffering from non-specific urethritis. Fourteen (9.9%) of these isolates were resistant to oxytetracycline and minocycline and they belonged to various serotypes. An increased resistance to minocycline was induced in 3 of 4 minocycline-sensitive ureaplasmas by passing them in vitro in the presence of this antibiotic. They did not attain the degree of resistance shown by naturally-occurring resistant strains and it was not possible to transfer resistance from these strains to those which were sensitive to minocycline. Naturally-occurring tetracycline-resistant ureaplasmas and those in which resistance had been induced retained an unaltered susceptibility to erythromycin.
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Evans et al. (1978) studied this question.