August 1, 1997Journal of Biological ChemistryOpen Access

Adenovirus E1A Inhibits Cardiac Myocyte-specific Gene Expression through Its Amino Terminus

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Population

Cardiac myocytes

Comparison

Adenovirus E1A oncoproteins vs Control

Design

Preclinical

Authors

NBNanette H. BishopricGeorgetown University BSBarbara SatoSRI International KWKeith A. WebsterVascular / Pulmonary Vascular

Discussion

Member takes

Implication

May limit E1A-based vectors for cardiac gene delivery; leaves open distinct mechanisms for myocyte-specific promoters.

Structured PICO

Population

Cardiac myocytes

Intervention

Adenovirus E1A oncoproteins

Comparator

Control (absence of E1A or ubiquitous β-actin promoter)

Outcome

Inhibition of myocyte-specific promoters (α-actins and α-myosin heavy chain)surrogate

Adenovirus E1A inhibits cardiac-specific gene expression via its amino-terminal domain, utilizing a distinct mechanism from general promoter inhibition.

Cite This Study

Bishopric et al. (1997) studied this question.

synapsesocial.com/papers/6a83365ec4b5dbf8331f3663 https://doi.org/10.1074/jbc.272.33.20584

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Adenovirus E1A Inhibits Cardiac Myocyte-specific Gene Expression through Its Amino Terminus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adenovirus E1A Inhibits Cardiac Myocyte-specific Gene Expression through Its Amino Terminus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider