Antithrombotic Therapy in Transcatheter Aortic Valve Replacement

Figures

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  Figure 1. Incidence of stroke and bleeding after TAVR at 30 days reported in PARTNER and PARTNER 3 Trials (2, 4).

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  Figure 2. The duration of DAPT or OAC therapy varied widely among centers, reported in the study “Evaluation of current practices in transcatheter aortic valve implantation: The WRITTEN (19).” DAPT, dual antiplatelet therapy; ASA, acetylsalicylic acid; OAC, oral anticoagulant; VKA, Vitamin K antagonists.

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  Figure 3. Rates of major or life-threatening events, ischemic stroke or TIA, MI and death after TAVR in DAPT vs. SAPT patients at 3 months, reported in “The ARTE” study (23). DAPT, dual antiplatelet therapy; SAPT, single antiplatelet therapy; LT, life-threatening; TIA, transient ischemic attack; MI, myocardial infarction.

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  Figure 4. The occurrence of the 30-day combined primary end point (occurrence of death, major, or life-threatening bleedings, and major vascular complications at 30-day follow-up) and rate of major or life-threatening bleeding events after TAVR, reported in the study “Meta-Analysis Comparing Single vs. Dual Antiplatelet Therapy Following Transcatheter Aortic Valve Implantation (25).” DAPT, dual antiplatelet therapy; SAPT, single antiplatelet therapy; LT, life-threatening.

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  Figure 5. Natural progression and/or regression of subclinical leaflet thrombosis (SLT) in transcatheter heart valves (THV). When left untreated, this may lead to clinically overt leaflet thrombosis, leading to structural valve deterioration and a potential increase in the risk of cerebrovascular events. HALT, hypo attenuated leaflet thickening; HAM, hypoattenuation affecting motion (38).

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  Figure 6. Institutional approach for antiplatelet therapy following TAVR.