Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 21, 2013AJP Heart and Circulatory Physiology

Scalability and in vivo validation of a multiscale numerical model of the left coronary circulation

View Full Paper
Ask AI
Bookmark
Share

Population

9 adult sheep and 9 newborn lambs

Comparison

Multiscale numerical model of the left coronary… vs In vivo measured high-fidelity hemodynamic data

Design

Preclinical

Authors

DPDaniel J. PennyBaylor College of MedicineJSJoseph J. SmolichThe University of Melbourne

Discussion

Loading...

Member takes

Implication

Model validation in sheep supports coronary hemodynamics simulations; leaves open age-related wave effects in humans.

Structured PICO

P
Population
9 adult sheep and 9 newborn lambs
I
Intervention
Multiscale numerical model of the left coronary circulation (1D network of major conduit arteries and lumped parameter model of microvascular beds)
C
Comparator
In vivo measured high-fidelity hemodynamic data
O
Outcome
Agreement between simulated and measured circumflex coronary flow (CxQ) waveformssurrogate

A multiscale numerical model of the left coronary circulation was successfully validated against in vivo data from adult and newborn sheep, demonstrating its utility for investigating coronary hemodynamics.

Cite This Study

Penny et al. (2013) studied this question.

synapsesocial.com/papers/6a8336b2d7df55868faf903chttps://doi.org/10.1152/ajpheart.00603.2013
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A method-of-characteristics calculation of coronary blood flow1977 · 29 citations
  2. 2Regional myocardial blood flow and oxygen delivery in fetal, newborn, and adult sheep1982 · 55 citations
  3. 3Left and right ventricular myocardial morphometry in fetal, neonatal, and adult sheep1989 · 139 citations
  4. 4Structured tree outflow condition for blood flow in larger systemic arteries1999 · 441 citations
  5. 5Interaction Between Intramyocardial Pressure (IMP) and Myocardial Circulation1985 · 82 citations