Why the study?
Do dihydropyridine-type Ca2+ antagonists and hydralazine improve renal arterial tree remodeling in spontaneously hypertensive rats?
Do dihydropyridine-type Ca2+ antagonists and hydralazine improve renal arterial tree remodeling in spontaneously hypertensive rats?
Dihydropyridine calcium channel blockers provide structural benefits to the renal arterial tree in hypertensive rats beyond simple vasodilation.
Should not change practice; leaves open translation of differential remodeling effects to human hypertension.
The effects of hypertension and of treatment with dihydropyridine-type Ca2+ antagonists and the vasodilator hydralazine on renal arterial tree were investigated in spontaneously hypertensive rats (SHR) with quantitative microanatomical techniques. Pharmacological treatment decreased to a similar extent systolic blood pressure values in SHR. Increased thickness of the tunica media of intrarenal arteries accompanied and luminal narrowing were observed in control SHR. Lercanidipine, manidipine, and nicardipine significantly countered wall thickening and luminal narrowing. Hydralazine countered luminal narrowing only. Dihydropyridines exerted renal vasocilatory activity primarily on resistance arteries, being lercanidipine the only compound active on small sized arteries.
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Sabbatini et al. (2002) studied this question.
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