Why the study?
Do dihydropyridine calcium antagonists improve cardiovascular mass and function in normotensive and spontaneously hypertensive rats?
Do dihydropyridine calcium antagonists improve cardiovascular mass and function in normotensive and spontaneously hypertensive rats?
Dihydropyridine calcium antagonists demonstrate subtle functional and structural differences in their effects on cardiovascular mass and function in hypertensive versus normotensive rat models.
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Highlights subtle strain-specific effects in rat models; leaves open human translation and should not alter practice.
Fröhlich et al. (1992) studied this question.
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