September 1, 1987HypertensionOpen Access

Role of nisoldipine on blood pressure, cardiac hypertrophy, and atrial natriuretic peptides in spontaneously hypertensive rats.

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Why the study?

Does nisoldipine prevent hypertension, cardiac hypertrophy, and elevated ANP levels in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats and Wistar-Kyoto rats of the same age, including old SHR with manifest…

Design

Preclinical

Follow-up

long-term

Authors

JSJ.-P. StaschAlbert Einstein College of Medicine SKS. KazdaMiles College CHC. HirthLaboratoire de Biophotonique et Pharmacologie

Discussion

Member takes

Implication

Hypothesis-generating in SHR; leaves open translation to human hypertension or heart failure prevention.

Structured PICO

Does nisoldipine prevent hypertension, cardiac hypertrophy, and elevated ANP levels in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) of the same age, including old SHR with manifest cardiac failure in end-stage hypertension

Intervention

Long-term treatment with nisoldipine

Outcome

Development of hypertension, cardiac hypertrophy, and plasma levels of atrial natriuretic peptides (ANP)surrogate

Nisoldipine prevents the development of hypertension and cardiac hypertrophy, and reduces elevated ANP levels in spontaneously hypertensive rats, including those with end-stage heart failure.

Cite This Study

Stasch et al. (1987) studied this question.

synapsesocial.com/papers/6a83366bc4b5dbf8331f3665 https://doi.org/10.1161/01.hyp.10.3.303

Topics

Hypertension management

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