Why the study?
Does nisoldipine or minoxidil improve blood pressure, cardiac hypertrophy, and ANP levels in salt-loaded Dahl rats?
Does nisoldipine or minoxidil improve blood pressure, cardiac hypertrophy, and ANP levels in salt-loaded Dahl rats?
Nisoldipine, unlike minoxidil, reduces cardiac hypertrophy and ANP levels in addition to lowering blood pressure in salt-sensitive hypertensive rats.
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Nisoldipine may regress hypertrophy beyond BP reduction in salt-sensitive models; leaves open translation to human hypertension.
Stasch et al. (1990) studied this question.
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