Key result
Nifedipine prevents blood pressure increases and reduces heart hypertrophy and mortality in salt-loaded Dahl rats.
Why the study?
Does nifedipine prevent malignant hypertension and heart hypertrophy in salt-loaded "S" Dahl rats?
Does nifedipine prevent malignant hypertension and heart hypertrophy in salt-loaded "S" Dahl rats?
Nifedipine prevents malignant hypertension, heart hypertrophy, and mortality in salt-loaded Dahl rats, likely through improvements in intrarenal hemodynamics and systemic vascular resistance.
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Nifedipine protects salt-loaded Dahl rats from hypertension sequelae; leaves open translation to human salt-sensitive hypertension.
Kazda et al. (1982) studied Malignant hypertension. Nifedipine vs. 8% NaCl diet alone was evaluated on Blood pressure, heart hypertrophy, and mortality. Nifedipine treatment prevented the increase in blood pressure, reduced heart hypertrophy and mortality, and improved impaired renal function in salt-loaded female 'S' Dahl rats.
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