Population
Conscious Dahl salt-sensitive (S) and salt-resistant (R) rats
Comparison
Intravenous isotonic sodium chloride load… vs Dahl R rats (salt-resistant)
Design
Preclinical
Follow-up
14 days
Authors
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Hypothesis-generating for salt-sensitive hypertension mechanisms; should not change clinical practice.
Prehypertensive Dahl salt-sensitive rats exhibit a blunted natriuretic response to isotonic saline and an early increase in extracellular fluid volume on a high-salt diet, suggesting a mechanism for salt-induced hypertension.
Roman et al. (1987) studied this question.
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