Population
Dahl strain rats (hypertension-resistant [R] and hypertension-sensitive [S])
Comparison
High salt chow for 4 weeks vs Normal salt chow for 4 weeks
Design
Preclinical
Follow-up
4 weeks
Authors
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Impaired renal vasodilation may underlie salt sensitivity in Dahl rat models; leaves open translation to human hypertension.
Hypertension-sensitive Dahl rats fail to exhibit renal vasodilation during high salt ingestion, maintaining inappropriately high renal vascular tone independent of neurogenic activity or reactivity to angiotensin II or norepinephrine.
Fink et al. (1980) studied this question.
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