Population
Dahl salt-sensitive and Dahl salt-resistant rats fed low or high salt diets
Comparison
Stepwise elevation of renal arterial pressure vs Dahl salt-resistant rats and low salt diet groups
Design
Preclinical
Authors
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May explain salt-sensitive hypertension via impaired autoregulation; leaves open translation to human disease.
Diminished myogenic responsiveness of preglomerular microvessels in Dahl salt-sensitive rats contributes to impaired renal autoregulation, providing mechanistic insight into salt-sensitive hypertension.
Takenaka et al. (1992) studied this question.
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