October 1, 1992HypertensionOpen Access

Impaired renal vascular reactivity in prehypertensive Dahl salt-sensitive rats.

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Population

Prehypertensive Dahl salt-sensitive and salt-resistant rats fed 1% NaCl diets

Comparison

Infusion of atrial natriuretic peptide… vs Salt-resistant rats

Design

Preclinical

Authors

SSShlomoh SimchonPulmonary Hypertension Association WMWilliam M. MangerCleveland Clinic GSGuoshuai ShiXi'an Medical University

Discussion

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Implication

Does not support clinical hypertension practice changes; hypothesis-generating for renal vascular mechanisms in salt-sensitive models.

Structured PICO

Population

Prehypertensive Dahl salt-sensitive and salt-resistant rats fed 1% NaCl diets

Intervention

Infusion of atrial natriuretic peptide, nitroprusside, norepinephrine, angiotensin II, and endothelin-1

Comparator

Salt-resistant rats (comparing responses between strains)

Outcome

Renal and nonrenal vascular resistancesurrogate

Prehypertensive Dahl salt-sensitive rats exhibit impaired renal vasodilation and hypersensitivity to renal vasoconstrictors compared to salt-resistant rats.

Cite This Study

Simchon et al. (1992) studied this question.

synapsesocial.com/papers/6a7e66113565a0595cc76dae https://doi.org/10.1161/01.hyp.20.4.524

Topics

Hypertension management

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Impaired renal vascular reactivity in prehypertensive Dahl salt-sensitive rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Impaired renal vascular reactivity in prehypertensive Dahl salt-sensitive rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider