Why the study?
Does dietary salt intake affect plasma and renal prorenin/renin parameters and blood pressure differently in Dahl salt-sensitive versus salt-resistant rats?
Population
Maturing Brookhaven Dahl salt-sensitive (Dahl S) and salt-resistant (Dahl R) rats (7 to 9 weeks old)
Comparison
Low (0%), medium (0.4%), or high (4%) NaCl diets vs Different NaCl diets and comparison between Dahl…
Design
Preclinical
Follow-up
14 days
Authors
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May delay salt-induced BP rise in Dahl S rats; leaves open translation to human salt-sensitive hypertension.
Does dietary salt intake affect plasma and renal prorenin/renin parameters and blood pressure differently in Dahl salt-sensitive versus salt-resistant rats?
The renin system in Dahl salt-resistant rats is unresponsive to high salt diets, whereas suppression of plasma renin in Dahl salt-sensitive rats may delay salt-induced blood pressure rises.
Campbell et al. (1996) studied this question.
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