Why the study?
Does a high-salt diet alter pressure natriuresis and renal blood flow in Dahl salt-sensitive rats compared to salt-resistant rats?
Population
18- to 20-wk-old, Inactin-anesthetized, inbred Dahl salt-sensitive (S/Jr) and salt-resistant (R/Jr) rats
Comparison
High (8.0%) sodium chloride diet vs Low sodium chloride diet and comparison between…
Design
Preclinical
Authors
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Preclinical Dahl rat data warrant no clinical changes; leaves open renal mechanisms in human salt-sensitive hypertension.
Does a high-salt diet alter pressure natriuresis and renal blood flow in Dahl salt-sensitive rats compared to salt-resistant rats?
In Dahl salt-sensitive rats, hypertension development is associated with an altered pressure-natriuresis relationship and reduced cortical and papillary blood flows when exposed to a high-salt diet.
Roman et al. (1991) studied this question.
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