Why the study?
Does renal denervation prevent the development of hypertension in Dahl salt-sensitive rats exposed to a high sodium diet?
Population
Dahl salt-sensitive rats (DS), n=13
Comparison
Renal denervation prior to switching from a low… vs Intact renal innervation prior to switching from…
Design
Preclinical
Follow-up
12 days
Authors
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Renal denervation does not prevent salt-induced hypertension in Dahl rats; hypothesis-generating for renal nerve contributions in human salt-sensitive hypertension.
Does renal denervation prevent the development of hypertension in Dahl salt-sensitive rats exposed to a high sodium diet?
Renal innervation is not required for the development of salt-induced hypertension in Dahl salt-sensitive rats, although it plays a role in sodium and water reabsorption.
Osborn et al. (1988) studied this question.
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