December 1, 1987Canadian Journal of Physiology and Pharmacology
Failure of renal denervation to attenuate hypertension in Dahl NaCl-sensitive rats
Why the study?
Does bilateral phenol renal denervation prevent hypertension in Dahl NaCl-sensitive rats on a high NaCl diet?
Population
Dahl NaCl-sensitive rats and normotensive Dahl NaCl-resistant rats
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Renal denervation ineffective in Dahl salt-sensitive model; leaves open renal nerve contribution to human salt-sensitive hypertension.
Structured PICO
Does bilateral phenol renal denervation prevent hypertension in Dahl NaCl-sensitive rats on a high NaCl diet?
P
Population
Dahl NaCl-sensitive rats and normotensive Dahl NaCl-resistant rats
I
Intervention
Bilateral phenol renal denervation prior to initiation of a high NaCl (8% NaCl) diet
O
Outcome
Systolic blood pressuresurrogate
Renal denervation does not attenuate hypertension in Dahl NaCl-sensitive rats, indicating that renal nerves do not provide a major contribution to hypertension in this specific genetic model.
Cite This Study
Wyss et al. (1987) studied this question.