Why the study?
Does complete renal denervation or selective afferent renal denervation reduce mean arterial pressure in hypertensive Dahl salt-sensitive rats?
Population
Hypertensive Dahl salt-sensitive rats in early phase and late phase
Comparison
Complete renal denervation or selective ablation… vs Sham surgery
Design
Preclinical
Authors
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RDN efficacy independent of afferent ablation in this model; leaves open dominant mechanism and clinical translation in human hypertension.
Does complete renal denervation or selective afferent renal denervation reduce mean arterial pressure in hypertensive Dahl salt-sensitive rats?
The antihypertensive effect of renal denervation in Dahl salt-sensitive rats is not due to ablation of afferent renal nerves, suggesting efferent nerves play the primary role.
Foss et al. (2015) studied this question.
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