Why the study?
Does renal denervation reduce arterial pressure in rats with salt-sensitive hypertension and reduced renal mass?
Population
Rats with ~80% surgical excision of renal mass fed a high salt diet
Comparison
Renal denervation of the remnant kidney vs Pre-denervation state
Design
Preclinical
Follow-up
2 weeks
Authors
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Renal denervation yields only transient BP reduction in this rat model; leaves open its chronic utility in salt-sensitive hypertension with nephron loss.
Does renal denervation reduce arterial pressure in rats with salt-sensitive hypertension and reduced renal mass?
Renal denervation does not chronically lower arterial pressure in a rat model of salt-sensitive hypertension associated with substantial nephron loss without ischemia and increased sympathetic activity.
Tudorancea et al. (2018) studied this question.
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