Why the study?
Does high salt intake and brain 'ouabain' blockade alter brain renin-angiotensin system activity in Dahl salt-sensitive rats?
Does high salt intake and brain 'ouabain' blockade alter brain renin-angiotensin system activity in Dahl salt-sensitive rats?
High salt intake increases blood pressure and brain ACE expression and activity in Dahl salt-sensitive rats, an effect that appears to be mediated by the activation of brain 'ouabain'.
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Brain ouabain may mediate salt-induced brain RAS changes in Dahl S models; leaves open relevance to human salt-sensitive hypertension.
Zhao et al. (2001) studied this question.