Why the study?
Does intracerebroventricular Na+-rich aCSF increase blood pressure and sympathetic nerve activity more in Dahl salt-sensitive rats compared to salt-resistant rats?
Population
Conscious young and adult Dahl salt-sensitive and salt-resistant rats, as well as weight-matched Wistar rats
Comparison
Acute and chronic intracerebroventricular… vs Intracerebroventricular infusions of standard…
Design
Preclinical
Follow-up
14 days
Authors
Loading...
Central Na+ may drive sympathetic hypertension in salt-sensitive models; leaves open human translation and requires clinical studies.
Does intracerebroventricular Na+-rich aCSF increase blood pressure and sympathetic nerve activity more in Dahl salt-sensitive rats compared to salt-resistant rats?
Genetic control of mechanisms linking cerebrospinal fluid Na+ with brain 'ouabain' is altered in Dahl salt-sensitive rats, predisposing them to sympathetic hyperactivity and severe hypertension.
Huang et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: