April 1, 1998AJP Heart and Circulatory Physiology

Brain “ouabain,” ANG II, and sympathoexcitation by chronic central sodium loading in rats

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Population

Wistar rats

Comparison

Intracerebroventricular infusion of sodium-rich… vs Intracerebroventricular infusion of artificial CSF

Design

Preclinical

Follow-up

14 days

Authors

BHBing HuangShihezi University SVShereeni J. VeerasinghamUniversity of Alabama at Birmingham FLFrans H. H. LeenenPreventive Cardiology

Discussion

Member takes

Implication

Central sodium may promote hypertension via brain ouabain and RAS in rats; hypothesis-generating for human salt-sensitive mechanisms.

Structured PICO

Population

Wistar rats

Intervention

Intracerebroventricular infusion of sodium-rich artificial CSF (0.8 or 1.2 M sodium) for 14 days, alone or concomitantly with antibody Fab fragments binding ouabain, gamma-globulins (200 micrograms/day), or losartan (1 mg.kg-1.day-1)

Comparator

Intracerebroventricular infusion of artificial CSF (aCSF)

Outcome

Changes in baseline mean arterial pressure (MAP), heart rate (HR), renal sympathetic nerve activity (RSNA), and baroreflex controlsurrogate

In Wistar rats, chronic central sodium loading induces sympathoexcitation and hypertension through mechanisms involving brain "ouabain" and the renin-angiotensin system.

Cite This Study

Huang et al. (1998) studied this question.

synapsesocial.com/papers/6a7dc88ee5d85d18548c9bf2 https://doi.org/10.1152/ajpheart.1998.274.4.h1269

View Full Paper

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Brain “ouabain,” ANG II, and sympathoexcitation by chronic central sodium loading in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Brain “ouabain,” ANG II, and sympathoexcitation by chronic central sodium loading in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider