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July 1, 1999HypertensionOpen Access

Brain Renin-Angiotensin System and Ouabain-Induced Sympathetic Hyperactivity and Hypertension in Wistar Rats

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Key result

Chronic administration of ouabain in Wistar rats significantly increased resting mean arterial pressure compared to controls (111 vs 93 mm Hg; P<0.05), which was prevented by concomitant losartan.

Why the study?

Does central administration of losartan prevent ouabain-induced sympathetic hyperactivity and hypertension in Wistar rats?

Population

Wistar rats

Comparison

Subcutaneous ouabain and intracerebroventricular… vs Control rats and rats treated with subcutaneous…

Design

Preclinical

Follow-up

15 days

Authors

BHBing HuangShihezi UniversityFLFrans H. H. LeenenPreventive Cardiology

Discussion

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Implication

Supports brain RAS role in sympathetic hypertension models; leaves open translation to human therapy.

Key Points

  • This study aims to determine whether the hypertension caused by ouabain is linked to the brain renin-angiotensin system.
  • Wistar rats received subcutaneous infusion of ouabain for 14 days using osmotic minipumps.
  • One group was treated with the angiotensin II type 1 receptor blocker losartan via intracerebroventricular infusion.
  • Various cardiovascular parameters were recorded in response to stress and drug challenges.
  • Ouabain treatment increased resting mean arterial pressure (111±4 vs. 93±3 mm Hg; P<0.05).
  • Enhanced cardiovascular responses to stress in ouabain-treated rats were prevented by concomitant losartan administration.
  • Chronic ouabain administration impaired baroreflex function and increased sympathoexcitation.

Structured PICO

Does central administration of losartan prevent ouabain-induced sympathetic hyperactivity and hypertension in Wistar rats?

P
Population
Wistar rats treated with subcutaneous ouabain for 14 days to assess the role of the brain renin-angiotensin system in hypertension.
I
Intervention
Subcutaneous ouabain (50 micrograms/d) and intracerebroventricular losartan (1 mg/kg per day) for 14 days
C
Comparator
Control rats and rats treated with subcutaneous ouabain alone
O
Outcome
Mean arterial pressure, heart rate, central venous pressure, and renal sympathetic nerve activity at rest and in response to stimuli on day 15surrogate

Main Result

Absolute Event Rate: 111% vs 93%

p-value: p=<0.05

Chronic administration of ouabain activates the brain renin-angiotensin system, leading to hypertension and sympathetic hyperactivity, which can be prevented by central AT1 receptor blockade.

Cite This Study

Huang et al. (1999) studied Hypertension. Ouabain with or without losartan vs. Control rats was evaluated on Resting mean arterial pressure (p=<0.05). Chronic administration of ouabain in Wistar rats significantly increased resting mean arterial pressure compared to controls (111 vs 93 mm Hg; P<0.05), which was prevented by concomitant losartan.

synapsesocial.com/papers/6a3300fbc832e26dfd08bf15https://doi.org/10.1161/01.hyp.34.1.107

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Brain “ouabain,” ANG II, and sympathoexcitation by chronic central sodium loading in rats1998 · 56 citations
  2. 2Brain “Ouabain” and Angiotensin II in Salt-Sensitive Hypertension in Spontaneously Hypertensive Rats1996 · 78 citations
  3. 3Chronic central versus peripheral ouabain, blood pressure, and sympathetic activity in rats.1994 · 101 citations
  4. 4Brain ‘Ouabain’ Mediates Sympathetic Hyperactivity in Congestive Heart Failure1995 · 78 citations
  5. 5Sodium responsiveness of central alpha 2-adrenergic receptors in spontaneously hypertensive rats.1988 · 48 citations