Why the study?
Does chronic ouabain administration cause hypertension by increasing sympathetic activity in normotensive rats?
Population
Conscious normotensive Wistar rats
Design
Preclinical
Follow-up
10 to 14 days
Authors
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Remains preclinical only; leaves open relevance of ouabain sympathoexcitation to human hypertension.
Does chronic ouabain administration cause hypertension by increasing sympathetic activity in normotensive rats?
Exogenous ouabain acts centrally to cause sympathoexcitation and hypertension in normotensive rats, regardless of the mode of administration.
Huang et al. (1994) studied this question.
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