August 1, 2001Brazilian Journal of Medical and Biological ResearchOpen Access

Effects of small doses of ouabain on the arterial blood pressure of anesthetized hypertensive and normotensive rats

View Full Paper

Ask AI

Bookmark

Why the study?

Does ouabain pretreatment enhance pressor reactivity in hypertensive and normotensive rats?

Population

Anesthetized normotensive (control and uninephrectomized) and hypertensive (1K1C and DOCA-salt treated) rats

Comparison

Ouabain pretreatment and 10 nM ouabain perfusion… vs Responses compared between normotensive and…

Design

Preclinical

Authors

LRLuciana Venturini RossoniInstitute of Biophysics and Biomedical Engineering VPVicente de Paulo Teixeira PintoUniversidade Federal do Ceará DVDalton Valentim VassalloUniversidade Federal do Espírito Santo

Discussion

Member takes

Implication

Ouabain may enhance pressor reactivity more in hypertensive rat models; hypothesis-generating for endogenous ouabain in human hypertension.

Structured PICO

Does ouabain pretreatment enhance pressor reactivity in hypertensive and normotensive rats?

Population

Anesthetized normotensive (control and uninephrectomized) and hypertensive (1K1C and DOCA-salt treated) rats

Intervention

Ouabain pretreatment (0.18 microg/kg, 18 microg/kg, and 1.8 mg/kg) and 10 nM ouabain perfusion in isolated tail vascular beds

Comparator

Responses compared between normotensive and hypertensive rat models

Outcome

Phenylephrine (PHE)-evoked pressor responses and changes in systolic and diastolic blood pressuresurrogate

Very small doses of ouabain enhance pressor reactivity in DOCA-salt hypertensive rats, suggesting endogenous ouabain may contribute to increased vascular tone in hypertension.

Cite This Study

Rossoni et al. (2001) studied this question.

synapsesocial.com/papers/6a8a79799be9d02581bdb4f1 https://doi.org/10.1590/s0100-879x2001000800014

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Implication

Ouabain may enhance pressor reactivity more in hypertensive rat models; hypothesis-generating for endogenous ouabain in human hypertension.

Effects of small doses of ouabain on the arterial blood pressure of anesthetized hypertensive and normotensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Effects of small doses of ouabain on the arterial blood pressure of anesthetized hypertensive and normotensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider