Key result
Ouabain pretreatment at nanomolar concentrations sensitized vascular smooth muscle to phenylephrine-evoked pressor responses in both normotensive and hypertensive rats in vitro and in vivo.
Why the study?
Does ouabain pretreatment increase phenylephrine-evoked pressor responses in normotensive and hypertensive rats?
Population
Normotensive and hypertensive rats in vivo (under anesthesia) and perfused rat tail vascular beds
Design
Preclinical
Authors
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May enhance vascular reactivity in rat models; hypothesis-generating for hypertension mechanisms with no human implications yet.
Does ouabain pretreatment increase phenylephrine-evoked pressor responses in normotensive and hypertensive rats?
Ouabain at nanomolar concentrations sensitizes vascular smooth muscle to vasopressor stimuli, suggesting a mechanism for increased vascular tone in hypertension.
Vassallo et al. (1997) studied Hypertension (animal model). Ouabain was evaluated on Phenylephrine (PE)-evoked pressor responses. Ouabain pretreatment at nanomolar concentrations sensitized vascular smooth muscle to phenylephrine-evoked pressor responses in both normotensive and hypertensive rats in vitro and in vivo.
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