Why the study?
Does long-term ouabain treatment alter vascular reactivity and Na+, K+-ATPase activity in the aorta of normotensive and hypertensive rats?
Population
Male Wistar rats and spontaneously hypertensive rats (SHRs)
Comparison
Ouabain for 5 and 20 weeks and 5 weeks vs Vehicle
Design
Preclinical
Follow-up
5 and 20 weeks
Authors
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May alter vascular tone in rat models via NO/COX-2; leaves open translation to human hypertension therapy.
Does long-term ouabain treatment alter vascular reactivity and Na+, K+-ATPase activity in the aorta of normotensive and hypertensive rats?
Long-term ouabain treatment reduces α-adrenergic vasoconstriction in rat aortas by enhancing NO synthesis and Na+, K+-ATPase activity while reducing COX-2-derived vasoconstrictors.
Davel et al. (2013) studied this question.
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