Why the study?
Does chronic ouabain treatment exacerbate blood pressure elevation in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats
Comparison
Chronic ouabain treatment vs Untreated SHRs and Wistar-Kyoto rats
Design
Preclinical
Follow-up
5 weeks
Authors
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May implicate ouabain-COX-2 pathway in SHR hypertension; hypothesis-generating for human translation.
Does chronic ouabain treatment exacerbate blood pressure elevation in spontaneously hypertensive rats?
Chronic ouabain treatment exacerbates hypertension in spontaneously hypertensive rats via vascular mechanisms involving reduced NO influence and increased COX-2-derived vasoconstrictor prostanoids.
Xavier et al. (2009) studied this question.
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