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May 1, 1994Journal of Hypertension

Ouabain-induced hypertension in the rat

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Why the study?

Does continuous ouabain infusion induce hypertension in normal and adrenalectomized rats?

Population

Normal and adrenalectomized male Sprague-Dawley rats

Design

Preclinical

Follow-up

5 weeks

Authors

PMPaolo ManuntaGeneral / Preventive / LipidsARAmy C. RogowskiUniversity of Maryland, BaltimoreBHBruce P. HamiltonUniversity of Mary

Discussion

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Implication

Does not inform human hypertension management; leaves open ouabain's role while providing a novel adrenal-independent rat model.

Structured PICO

Does continuous ouabain infusion induce hypertension in normal and adrenalectomized rats?

P
Population
Normal and adrenalectomized male Sprague-Dawley rats
I
Intervention
Ouabain administered via subcutaneous osmotic pumps (10 and 30 micrograms/kg per day) for 5 weeks
O
Outcome
Blood pressure, plasma and tissue ouabain levelssurrogate

Prolonged ouabain infusion in rats induces a reversible, adrenal-independent, and salt-insensitive form of hypertension, providing a model for exploring long-term blood pressure regulation.

Cite This Study

Manunta et al. (1994) studied this question.

synapsesocial.com/papers/6a813a2e17c102c671648d1bhttps://doi.org/10.1097/00004872-199405000-00008

Topics

Hypertension management
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Also Consider

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  1. 1Brain Renin-Angiotensin System and Ouabain-Induced Sympathetic Hyperactivity and Hypertension in Wistar Rats1999 · 75 citations
  2. 2Chronic central versus peripheral ouabain, blood pressure, and sympathetic activity in rats.1994 · 101 citations
  3. 3Effects of small doses of ouabain on the arterial blood pressure of anesthetized hypertensive and normotensive rats2001 · 20 citations
  4. 4Wistar Rats Resistant to the Hypertensive Effects of Ouabain Exhibit Enhanced Cardiac Vagal Activity and Elevated Plasma Levels of Calcitonin Gene-Related Peptide2014 · 13 citations
  5. 5Central and peripheral renin-angiotensin systems in ouabain-induced hypertension2006 · 30 citations