Key result
Chronic subcutaneous infusion of ouabain in rats increased blood pressure by 15 mmHg at 2 weeks, alongside increased hypothalamic ANG II and decreased central AT1 receptor and ACE densities.
Effect estimate: +15 mmHg
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No immediate clinical implications for hypertension; leaves open translation of central AT1 mechanisms from rat ouabain models.
Cheung et al. (2006) studied ouabain-induced hypertension. ouabain was evaluated on blood pressure (+15 mmHg). Chronic subcutaneous infusion of ouabain in rats increased blood pressure by 15 mmHg at 2 weeks, alongside increased hypothalamic ANG II and decreased central AT1 receptor and ACE densities.
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