Why the study?
Does long-term administration of exogenous ouabain cause hypertension in male Wistar rats?
Population
Male Wistar rats
Comparison
Ouabain administered subcutaneously for 3 months vs Control group
Design
Preclinical
Follow-up
3 months
Authors
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Chronic ouabain fails to raise BP in rats despite CGRP elevation; leaves open compensatory mechanisms and translational relevance.
Does long-term administration of exogenous ouabain cause hypertension in male Wistar rats?
Long-term administration of exogenous ouabain does not cause hypertension in Wistar rats, potentially due to compensatory increases in parasympathetic activity and vasodilatory CGRP.
Ghadhanfar et al. (2014) studied this question.
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