Key result
Anti-ouabain antibody dose-dependently lowers blood pressure in hypertensive rats with ~2-fold higher endogenous ouabain.
Why the study?
The role of endogenous ouabain in the development of hypertension in 1k1c hypertensive rats was evaluated to understand its contribution to blood pressure regulation.
Does anti-ouabain antibody reduce blood pressure in 1k1c hypertensive rats?
Does anti-ouabain antibody reduce blood pressure in 1k1c hypertensive rats?
Endogenous ouabain appears to play a significant role in the development of hypertension in 1k1c rats, as its antagonism dose-dependently reduces blood pressure.
Answers are grounded in this paper and cite their sources.
Endogenous ouabain antagonism lowers BP in this rat model; leaves open any therapeutic role in human hypertension.
This study was designed to evaluate the role of endogenous ouabain (EO) in the development of hypertension in 1ktc (one kidney, one clip) hypertensive rats. First, the EO content of the serum of 1k1c hypertensive rats and normal Sprague-Dawley (SD) rats was detected by the enzyme linked immunosorbent assay method (ELISA). Second, blood pressure changes in the 1k1c rats were recorded directly after the 1k1c rats were injected randomly with anti-ouabain antibody, normal rabbit IgG, and normal saline, respectively. The results showed that EO levels in the serum of 1k1c hypertensive rats were significantly higher than those of normal SD rats (2.25 +/-0.92 microg/l vs. 1.12 +/- 0.17 microg/l, p< 0.01), and correlated significantly with systolic blood pressure (r= 0.59, p< 0.05). Anti-ouabain antibody was able to significantly decrease the blood pressure of 1k1c hypertensive rats in a dose-dependent manner, while normal rabbit IgG or normal saline was not. These results indicate that endogenous ouabain might play an important role in the development of hypertension in 1k1c hypertensive rats.
No takes yet. Share an insight, caveat, or question.
Wei-qing et al. (2000) studied 1k1c hypertension (n=65). 1k1c hypertension model vs. Normal SD rats was evaluated on Serum endogenous ouabain (EO) levels (p=<0.01). Serum endogenous ouabain levels were higher in 1k1c hypertensive rats compared to normal rats, and administration of anti-ouabain antibody dose-dependently decreased blood pressure.
Synapse has enriched 10 related papers. Consider them for comparative context: