Key result
Sodium deficient diet caused a modest increase, and sodium deficient diet plus Captopril caused a very large increase in both renal renin and renal renin mRNA in both S and R rat strains.
Why the study?
Does sodium deficient diet with or without captopril affect renal renin and renin mRNA levels in Dahl salt-sensitive and salt-resistant rats?
Does sodium deficient diet with or without captopril affect renal renin and renin mRNA levels in Dahl salt-sensitive and salt-resistant rats?
Dahl salt-sensitive and salt-resistant rats regulate renin similarly in response to provocative stimuli like sodium depletion and captopril, despite baseline differences.
Answers are grounded in this paper and cite their sources.
Preserved renin responses in Dahl S rats despite baseline differences; hypothesis-generating for human salt-sensitive hypertension mechanisms.
It is known that inbred Dahl salt-sensitive (S) rats carry a different renin allele than inbred Dahl salt-resistant (R) rats. The levels of, and responses of, renal renin and renal renin mRNA to sodium deficient diet and to sodium deficient diet plus Captopril treatment were compared in S and R rats. S rats had lower renal renin and lower renal renin mRNA than R rats on control (1% NaCl) diet. Sodium deficient diet caused a modest increase, and sodium deficient diet plus Captopril caused a very large increase in both renal renin and renal renin mRNA in both strains. In general, both S and R strains appeared to regulate renin similarly in response to provocative stimuli.
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Dene et al. (1989) studied this question. Sodium deficient diet and sodium deficient diet plus Captopril vs. Control (1% NaCl) diet was evaluated on Levels of and responses of renal renin and renal renin mRNA. Sodium deficient diet caused a modest increase, and sodium deficient diet plus Captopril caused a very large increase in both renal renin and renal renin mRNA in both S and R rat strains.
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