Key result
Increased dietary sodium enhanced the antihypertensive response to nifedipine in spontaneously hypertensive rats, preventing the rise in blood pressure between 10 and 16 weeks of age.
Why the study?
Does increased dietary sodium enhance the antihypertensive effect of nifedipine in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) from 4 until 16 weeks of age
Comparison
Nifedipine added at 10 weeks of age with… vs Nifedipine added at 10 weeks of age with regular…
Design
Preclinical
Follow-up
12 weeks (from 4 to 16 weeks of age)
Authors
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Should not alter sodium intake with nifedipine in patients; leaves open dietary modulation of calcium-channel blocker efficacy in human hypertension.
Does increased dietary sodium enhance the antihypertensive effect of nifedipine in spontaneously hypertensive rats?
Modest increases in sodium intake enhance the blood pressure response to nifedipine in spontaneously hypertensive rats, possibly by potentiating its inhibitory effects on sympathetic activity.
Leenen et al. (1992) studied Hypertension. Increased dietary sodium and nifedipine vs. Regular dietary sodium (120 mumol Na+/g food) and nifedipine was evaluated on Blood pressure response. Increased dietary sodium enhanced the antihypertensive response to nifedipine in spontaneously hypertensive rats, preventing the rise in blood pressure between 10 and 16 weeks of age.
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