Why the study?
Does nifedipine reduce blood pressure and alter plasma renin activity and catecholamines in normotensive and hypertensive subjects?
Population
7 normal subjects and 19 patients with essential hypertension (total n=26)
Comparison
Nifedipine 10 mg sublingually, followed by… vs Normotensive controls and baseline measurements
Design
Cohort
Follow-up
3 weeks
Authors
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Nifedipine may lower BP without reflex tachycardia yet associate with sympathetic activation; leaves open net long-term effects on outcomes.
Does nifedipine reduce blood pressure and alter plasma renin activity and catecholamines in normotensive and hypertensive subjects?
Nifedipine is an effective antihypertensive agent that lowers blood pressure but induces some degree of sympathetic activation, as evidenced by increased plasma noradrenaline.
Corea et al. (1979) studied this question.
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