Why the study?
Does a single 20-mg sublingual dose of nifedipine improve blood pressure and renal function in patients with mild to moderate arterial hypertension insufficiently treated on beta-blocker monotherapy?
Population
10 patients with mild to moderate arterial hypertension insufficiently treated on beta-blocker monotherapy
Design
Cohort
Follow-up
Acute (single dose)
Authors
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May support acute BP lowering on beta-blockers; hypothesis-generating for renal effects, pending randomized trials.
Does a single 20-mg sublingual dose of nifedipine improve blood pressure and renal function in patients with mild to moderate arterial hypertension insufficiently treated on beta-blocker monotherapy?
Acute sublingual nifedipine effectively reduces blood pressure and maintains renal blood flow with diuretic and uricosuric effects in hypertensive patients inadequately controlled on beta-blockers.
Christensen et al. (1982) studied this question.
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