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October 1, 1989American Journal of HypertensionOpen Access

Antihypertensive and Humoral Effects of Nifedipine in Essential Hypertension Nifedipine in Essential Hypertension

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Why the study?

Does nifedipine added to hydrochlorothiazide reduce blood pressure in patients with essential hypertension inadequately controlled by hydrochlorothiazide alone?

Population

Patients with essential hypertension inadequately controlled by hydrochlorothiazide alone.

Comparison

Nifedipine capsules added to hydrochlorothiazide… vs Matching placebo added to hydrochlorothiazide…

Design

RCT, double-blind

Follow-up

10 weeks

Authors

JOJohn A. OpsahlCRC. E. RalstensonPAPaul A. Abraham

Discussion

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Overview

Nifedipine add-on to HCTZ lowers BP in uncontrolled essential hypertension; confirms efficacy of CCB-diuretic combination.

Structured PICO

Does nifedipine added to hydrochlorothiazide reduce blood pressure in patients with essential hypertension inadequately controlled by hydrochlorothiazide alone?

P
Population
Patients with essential hypertension inadequately controlled (seated diastolic blood pressure ≥ 95 mm Hg) by hydrochlorothiazide (HCTZ) alone.
I
Intervention
Nifedipine capsules (mean dose 43 +/- 16 mg daily) added to hydrochlorothiazide (50 mg daily) for 10 weeks.
C
Comparator
Matching placebo added to hydrochlorothiazide (50 mg daily) for 10 weeks.
O
Outcome
Change in seated blood pressure at 10 weekssurrogate

Nifedipine added to a diuretic effectively lowers blood pressure and is generally well-tolerated without stimulating the renin-angiotensin-aldosterone axis in patients with essential hypertension.

Cite This Study

Opsahl et al. (1989) studied this question.

synapsesocial.com/papers/6a7e37101bf3cbbc304f98e2https://doi.org/10.1093/ajh/2.11.828
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Short- and long-term efficacy of a calcium-antagonistic agent (nifedipine) combined with methyldopa in the treatment of severe hypertension.1980 · 165 citations
  2. 2Controlled Trial of Nifedipine and Bendroflumethiazide in Hypertension1983 · 68 citations
  3. 3Calcium-channel blockade with nifedipine and angiotensin converting-enzyme inhibition with captopril in the therapy of patients with severe primary hypertension.1984 · 120 citations
  4. 4A Double-Blind Study of the Blood Pressure Lowering Effect of a Thiazide Diuretic in Hypertensive Patients Already on Nifedipine and a Beta-Blocker1987 · 19 citations
  5. 5The Effects of Bendroflumethiazide Added to Nifedipine in Patients With Hypertension1987 · 10 citations