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October 1, 1982British Journal of Clinical PharmacologyOpen Access

Nifedipine in the treatment of hypertension: report of a double‐blind controlled trial.

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Why the study?

Does oral nifedipine reduce arterial pressure in patients with hypertension inadequately controlled by a beta-blocker or alpha-methyldopa and a diuretic?

Population

42 patients with hypertension in whom arterial pressure was not adequately controlled by the combination of…

Comparison

Oral nifedipine added to existing therapy in a… vs Placebo.

Design

RCT, double-blind

Authors

SBS. BayleySt George's, University of LondonRDRJ DobbsUniversity of ViennaBRB.F. RobinsonSt George's Hospital

Discussion

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Overview

Supports adding nifedipine for hypertension inadequately controlled on beta-blocker or methyldopa plus diuretic; confirms efficacy as add-on in this RCT.

Structured PICO

Does oral nifedipine reduce arterial pressure in patients with hypertension inadequately controlled by a beta-blocker or alpha-methyldopa and a diuretic?

P
Population
42 patients with hypertension in whom arterial pressure was not adequately controlled by the combination of a beta-adrenoceptor antagonist (or alpha-methyldopa) and a diuretic.
I
Intervention
Oral nifedipine (10 mg capsules) added to existing therapy in a final dose of 20-60 mg daily, or as a sustained release preparation.
C
Comparator
Placebo (in a double-blind, cross-over phase for 11 patients).
O
Outcome
Reduction in arterial pressure (supine and standing).surrogate

Nifedipine effectively reduces blood pressure when added to background therapy in patients with inadequately controlled hypertension.

Cite This Study

Bayley et al. (1982) studied this question.

synapsesocial.com/papers/6a7e46fcd2dab73675856556https://doi.org/10.1111/j.1365-2125.1982.tb02021.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nifedipine, a new antihypertensive with rapid action1977 · 249 citations
  2. 2Calcium Antagonists Decrease Adrenal and Vascular Responsiveness to Angiotensin II in Normal Man1981 · 58 citations
  3. 3Response of Forearm Resistance Vessels to Verapamil and Sodium Nitroprusside in Normotensive and Hypertensive Men: Evidence for a Functional Abnormality of Vascular Smooth Muscle in Primary Hypertension1982 · 95 citations
  4. 4Production of ischaemic cardiac pain by nifedipine.1978 · 124 citations
  5. 5Short- and long-term efficacy of a calcium-antagonistic agent (nifedipine) combined with methyldopa in the treatment of severe hypertension.1980 · 165 citations