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April 1, 1986Clinical Pharmacology & Therapeutics

Nifedipine tablet vs. hydralazine in patients with persisting hypertension who receive combined diuretic and beta-blocker therapy

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Why the study?

Does nifedipine compared to hydralazine improve blood pressure control in patients with persisting hypertension on combined diuretic and beta-blocker therapy?

Population

19 patients with persisting hypertension despite combined diuretic and beta-blocker therapy

Comparison

Nifedipine tablet added to combined diuretic and… vs Hydralazine added to combined diuretic and…

Design

RCT, randomized, double-blind, placebo-controlled

Follow-up

9 weeks

Authors

MMMartin G. MyersFLFrans H. H. LeenenRBRobert Burns

Discussion

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Overview

Supports nifedipine over hydralazine for add-on BP control on diuretic plus beta-blocker; extends RCT evidence for CCBs in resistant hypertension.

Structured PICO

Does nifedipine compared to hydralazine improve blood pressure control in patients with persisting hypertension on combined diuretic and beta-blocker therapy?

P
Population
19 patients with persisting hypertension (diastolic BP between 95 and 120 mm Hg) despite combined diuretic and beta-blocker therapy
I
Intervention
Nifedipine tablet (increasing doses: 20, 40, and 60 mg b.i.d. if tolerated or until goal BP achieved) added to combined diuretic and beta-blocker therapy
C
Comparator
Hydralazine (increasing doses: 25, 50, and 100 mg b.i.d. if tolerated or until goal BP achieved) added to combined diuretic and beta-blocker therapy
O
Outcome
Supine and standing blood pressuresurrogate

Nifedipine is an effective antihypertensive agent for patients with persisting hypertension despite combined diuretic and beta-blocker therapy.

Cite This Study

Myers et al. (1986) studied this question.

synapsesocial.com/papers/6a758aa2ef3d015f2ddd76d7https://doi.org/10.1038/clpt.1986.63
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nifedipine in the Treatment of Essential Hypertension1985 · 10 citations
  2. 2Antihypertensive and Humoral Effects of Nifedipine in Essential Hypertension Nifedipine in Essential Hypertension1989 · 4 citations
  3. 3Nifedipine in the treatment of hypertension: report of a double‐blind controlled trial.1982 · 64 citations
  4. 4Comparison of Nifedipine Alone and With Diltiazem or Verapamil in Hypertension1996 · 82 citations
  5. 5Evaluation of the Efficacy of Slow-Release Nifedipine in Systemic Hypertension by Ambulatory Intraarterial Blood Pressure Monitoring1985 · 20 citations