Why the study?
Does intravenous nifedipine alter renal hemodynamics differently in patients with essential hypertension compared to those with chronic glomerular nephritis or normotensive controls?
Population
n=47 subjects, including 12 with essential hypertension, 9 with chronic glomerular nephritis with…
Design
Other
Follow-up
45 min
Authors
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Renal arteriolar sensitivity may differ in essential hypertension; leaves open clinical relevance and needs confirmation in controlled trials.
Does intravenous nifedipine alter renal hemodynamics differently in patients with essential hypertension compared to those with chronic glomerular nephritis or normotensive controls?
Intravenous nifedipine increases GFR and RBF in patients with essential hypertension but not in those with chronic glomerular nephritis, suggesting distinct renal vascular pathophysiology and heightened sensitivity of renal arterioles in essential hypertension.
Yokoyama et al. (1983) studied this question.
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