Key result
Sublingual nifedipine rapidly lowers systolic and diastolic blood pressure within five minutes in essential hypertension.
Why the study?
The effects of sublingual nifedipine on arterial pressure, plasma renin activity, and glomerular filtration rate in essential hypertension were not fully characterized.
May support rapid BP reduction with sublingual nifedipine; leaves open confirmation of safety and efficacy in RCTs.
Effects of sublingual administration of nifedipine on systemic arterial pressure (BP), plasma renin activity (PRA), aldosterone level (AL), and serum sodium (Na) and potassium (K) levels, have been determined. A significant decrease was observed in systolic and diastolic blood pressure five minutes after the sublingual administration of nifedipine in 21 patients with mild or moderate essential hypertension. Furthermore, in an observation period of six hours, it was also established that the effect of nifedipine on systolic and diastolic blood pressure continued. An increase was observed in glomerular filtration rate, whereas there were no changes in PRA, AL, or serum Na and K levels.
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Yurtkuran et al. (1989) studied mild or moderate essential hypertension (n=21). Sublingual nifedipine was evaluated on Systemic arterial pressure, plasma renin activity, aldosterone level, serum sodium, serum potassium, and glomerular filtration rate. Sublingual nifedipine significantly decreased systolic and diastolic blood pressure within five minutes in patients with essential hypertension, with effects lasting up to six hours.
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