Why the study?
Does altering sodium balance affect the blood-pressure-lowering effect of nifedipine in normotensive and hypertensive subjects?
Population
Normotensive and hypertensive subjects
Design
Other
Authors
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May potentiate nifedipine response via salt loading without thiazide additivity; leaves open sodium-CCB interactions for prospective trials.
Does altering sodium balance affect the blood-pressure-lowering effect of nifedipine in normotensive and hypertensive subjects?
The blood-pressure-lowering effect of nifedipine is enhanced by increased salt intake but not by the addition of a thiazide diuretic, suggesting a physiological link between sodium balance and calcium channel blocker efficacy.
MacGregor et al. (1985) studied this question.
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