Why the study?
Does the withdrawal of long-term nifedipine affect sodium balance and blood pressure in patients with essential hypertension?
Population
8 patients with mild to moderate uncomplicated essential hypertension who had been taking nifedipine 20 mg…
Comparison
Withdrawal of nifedipine and replacement with… vs Baseline state while receiving nifedipine 20 mg…
Design
Other, Single blind
Follow-up
1 week
Authors
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Nifedipine withdrawal may induce sodium retention warranting clinical caution; leaves open mediation of long-term BP effects.
Does the withdrawal of long-term nifedipine affect sodium balance and blood pressure in patients with essential hypertension?
Nifedipine's blood pressure-lowering effect in essential hypertension may be partly mediated by a long-term reduction in sodium balance.
Pevahouse et al. (1990) studied this question.
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