Why the study?
Does nisoldipine improve renal and cardiac protection in severely hypertensive rats compared to atenolol, enalapril, or vehicle?
Population
24 six-week-old male spontaneously hypertensive rats given 100 mg/kg deoxycorticosterone and a 4% NaCl diet
Comparison
Nisoldipine (7 mg/kg) orally for 8 weeks vs Vehicle, atenolol, or enalapril orally for 8 weeks
Design
Preclinical
Follow-up
8 weeks
Authors
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Should not change clinical practice; leaves open whether nisoldipine confers unique renoprotection in human hypertension.
Does nisoldipine improve renal and cardiac protection in severely hypertensive rats compared to atenolol, enalapril, or vehicle?
In a rat model of severe hypertension, the calcium antagonist nisoldipine provided superior renoprotection compared to atenolol or enalapril despite similar blood pressure lowering.
Ishimitsu et al. (1994) studied this question.
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